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Effect of hydroxyurea on foetal haemoglobin in myeloproliferative & myelodysplastic syndromes.

Advani, S H; Venugopal, P; Charak, B S; Das Gupta, A; Mazumdar, A T; Gopal, R; Nair, C N; Saikia, T K; Nadkarni, K S; Kurkure, P A.

Article in English | IMSEAR | ID: sea-20895

ABSTRACT

The effect of hydroxyurea on foetal haemoglobin (HbF) levels was evaluated in 36 patients of myeloproliferative and myelodysplastic disorders. In 17 (47.2%) patients, HbF levels increased from 1.40 +/- 1.17 to 3.03 +/- 1.97 per cent after 4 wk therapy with hydroxyurea. In the responders this increase was highly significant (P less than 0.001). The rise in the HbF levels after hydroxyurea therapy was significant in patients with chronic myeloid leukaemia but not in the other groups.

Subject(s)

Adolescent , Adult , Aged , Child , Female , Fetal Hemoglobin/analysis , Humans , Hydroxyurea/pharmacology , Male , Middle Aged , Myelodysplastic Syndromes/blood , Myeloproliferative Disorders/blood

Splenomegaly and hepatomegaly at onset of blastic crisis in chronic myeloid leukaemia have prognostic importance.

Parikh, P M; Charak, B S; Banavali, S D; Koppikar, S B; Giri, N K; Kumar, A; Saikia, T K; Gopal, R; Mazumdar, A T; Advani, S H.

Article in English | IMSEAR | ID: sea-93143

Subject(s)

Adolescent , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Blast Crisis/drug therapy , Child , Female , Hepatomegaly , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Male , Middle Aged , Prognosis , Splenomegaly

ABSTRACT

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